UTI Resources

Opioids and Urinary Tract Infections

Studies show that opioid therapy may cause urine retention, a condition in which you are unable to empty the bladder during urination. Over time, urine retention can lead to a Urinary Tract Infection, a common and potentially dangerous infection, especially for immune-compromised patients or those undergoing chemotherapy. Furthermore, opioid therapy can mask the common symptoms of a UTI, making diagnosis challenging.

What do we know about Opioids and the Kidney?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297852/

Abstract: Urine retention is primary risk factor for UTI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502981/ 

Reversal of opioid-induced bladder dysfunction by intravenous naloxone and methylnaltrexone
https://pubmed.ncbi.nlm.nih.gov/17392726/ 

Bladder function in mice treated with opioids
https://pubmed.ncbi.nlm.nih.gov/34993265/ 

Drug-Induced Urinary Retention: Incidence, Management and Prevention
https://www.researchgate.net/publication/233495736_Drug-Induced_Urinary_Retention_Incidence_Management_and_Prevention

Effects of analgesic and anesthetic medications on lower urinary tract function
https://pubmed.ncbi.nlm.nih.gov/22690461/ 

Drug-induced urinary retention: incidence, management and prevention
https://pubmed.ncbi.nlm.nih.gov/18422378/

Urinary retention definition
Urinary Retention | NIDDK

Opioids and Bladder Pain/Function
https://link.springer.com/referenceworkentry/10.1007/978-3-540-29805-2_2975

MOVANTIK® (naloxegol) – Treatment for Opioid Induced Constipation (OIC)
https://pubmed.ncbi.nlm.nih.gov/32129103/

Intrathecal Opioids and Lower Urinary Tract Function: A Urodynamic Evaluation
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1942947 

Urinary Retention in Adults: Diagnosis and Initial Management
https://www.aafp.org/pubs/afp/issues/2008/0301/p643.html

Opioid-related side effects: Postoperative ileus, urinary retention
https://www.sciencedirect.com/science/article/abs/pii/S1521689617300423?via%3Dihub 

Nalbuphine for Opioid-Induced Urine Retention
https://www.acpjournals.org/doi/10.7326/L18-0387  

Reversal of opioid induced urinary retention after methylnaltrexone
https://pubmed.ncbi.nlm.nih.gov/22034654/ 

NIH UTI Overview
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875701/ 

Effects of analgesic and anesthetic medications on lower urinary tract function
https://link.gale.com/apps/doc/A288872475/AONE?u=googlescholar&sid=bookmark-AONE&xid=f26d6115

Severe urinary retention secondary to intrathecal morphine pain pump: A case report
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607156/

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