Molecular PCR UTI Test + ABR

Urinary Tract Infection Panel

Promus Diagnostics’ comprehensive molecular UTI panel provides a complete set of data much faster than traditional urine culture — making results more relevant, meaningful and reliable.

How other labs test for UTIs

Culture & Sensitivity

For over 50 years Culture and Sensitivity (“C&S”) has been considered the traditional “gold standard” to identify, diagnose and treat complicated UTIs. While C&S reports results in Colony Forming Units (CFU/ml) to provide treatment guidance (drug dosage and duration), C&S does not grow, identify or report ALL of the relevant pathogens in a specimen. The result is that some pathogens go undetected and untreated. Additionally, C&S requires up to 72 hours to complete. As a consequence, C&S prescribers treat patients empirically adding to globally recognized “antibiotic stewardship” risks.

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Standard PCR for UTI

Most PCR labs identify 15-20 relevant pathogens, 2-10 Antibiotic Resistant Genes and report results in 24-48 hours. While this is faster and more comprehensive than C&S, there are more than a dozen additional pathogens and resistant genes that most labs fail to detect and consequently will not be treated by the medical provider. More importantly, other labs report results in DNA copies/mL not CFU/ml. Unlike CFU/ml, DNA copies/ml is not consistent with established reporting methodology and offers limited diagnostic treatment guidance to the provider.

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brings the next evolution in UTI testing

The Promus Pathway is the next level of PCR reporting. Promus Pathway identifies and reports 30+ of the most relevant UTI pathogens and 20+ antibiotic resistant genes in the established CFU/ml reporting methodology. Promus Pathway’s CFU/ml reporting delivers faster, more comprehensive, and accurate treatment guidance (drug, dosage and duration) compared to C&S or standard PCR options. Unlike C&S which is only 57% accurate and takes as much as 72 hours, Promus Pathway produces test results in just 24 hours with 95%+ accuracy, eliminating the need to treat patients empirically and insuring the best possible antibiotic stewardship.

Promus is the only PCR lab to identify, isolate and design methods to proliferate over 100 live pathogens across multiple infectious disease assays and create a validated reporting algorithm that couples highly accurate results in CFUs/mL and all related antibiotic resistance genes. Promus is able to provide the only fully validated antibiotic treatment guidance that is easily translated into standard antibiotic dosing protocols for each pathogen and the associated antibiotic resistance genes.

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Pathogens
Promus Pathway Flyer
Promus Pathway vs. Culture or Standard PCR
Promus Pathway Patient Brochure
UTI Panel Sample Report

Antibiotic Resistance

Antibiotic resistance refers to the ability of an infection causing bacteria to resist the effects of antibiotics. According to the CDC, “each year in the United States at least 2.8 million antibiotic-resistant infections occur, and more than 35,000 people die as a result.”

Opioids & UTIs

Studies show that opioid therapy may cause urine retention. Over time, urine retention can lead to a Urinary Tract Infection, a common and potentially dangerous infection, especially for immune-compromised patients or those undergoing chemotherapy.

PCR vs Promus Pathway

The Promus Pathway is the next level of PCR reporting. Promus Pathway identifies and reports 30+ of the most relevant UTI pathogens and 20+ antibiotic resistant genes in the established CFU/ml reporting methodology.

Urinary Tract Infection
+ Antibiotic Resistance Genes (UTI+ABR)

Promus Diagnostics Molecular PCR UTI Test is the Solution

Urinary Tract Infections (UTI) are the most common bacterial infection among long term care residents and the second most common infection diagnosed in the acute hospital setting. UTIs account for almost 5% of all emergency department visits by adults aged 65 years and older in the United States each year.

Traditional testing for a UTI involves a urine culture which can take days to complete, greatly reducing sensitivity and accuracy. Without an accurate identification of the pathogen, healthcare providers may treat the patient with a course of antibiotics that may not be the optimal choice based on pathogens present resulting in persistent or recurring UTIs.

A recent study by Washington University found that of the 670,450 women tested, 46.7% “received antibiotic prescriptions for inappropriate agents” and 76.1% received antibiotics for an incorrect duration.1

At Promus Diagnostics we provide a better solution for identifying the pathogens causing an UTI using real-time PCR technology. Our UTI+ABR test panel can quickly and accurately identify 31 different infection causing pathogens and 22 antimicrobial resistance markers, giving healthcare providers the clearest and most robust information to develop a treatment regimen.

Improper diagnosis or ineffective treatment plan for a UTI could cause
  • Permanent kidney damage
  • Life-threatening sepsis
  • Ongoing discomfort
  • Chronic infections

Identification where culture or dipstick may not have detected infection, or inconclusive due to sample contamination

Reduce or eliminate recurrent infections based on superior identification of Uropathogens for proper treatment

Informed drug selection to remediate infection, decrease incidents of adverse events as well as lessen the potential for antibiotic resistance

“Antibiotic stewardship is the effort to measure and improve how antibiotics are prescribed by clinicians and used by patients.”2

Target Pathogens

  • Acinetobacter baumannii
  • Actinobaculum schaalii
  • Aerococcus urinae
  • Candida albicans
  • Candida auris
  • Candida glabrata
  • Candida parapsilosis
  • Citrobacter freundii
  • Citrobacter koseri
  • Coagulase Negative Staph
  • Corynebacterium riegelii
  • Enterobacter aerogenes
  • Enterobacter cloacae
  • Enterococcus faecalis
  • Enterococcus faecium
  • Escherichia coli
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Morganella morganii
  • Mycoplasma hominis
  • Pantoea agglomerans
  • Proteus mirabilis
  • Proteus vulgaris
  • Providencia stuartii
  • Pseudomonas aeruginosa
  • Serratia marcescens
  • Staphylococcus aureus
  • Streptococcus agalactiae
  • Ureaplasma urealyticum
  • Viridans Group Strep

Resistance Genes

  • ampC
  • DHA
  • IMP-1 group, IMP-16, IMP-7
  • OXA-23, OXA-72, OXA-40, blaOXA-48
  • VIM
  • KPC
  • CTX-M group 1, CTX-M group 2, CTX-M group 9, CTX-M group 8/25
  • SHV
  • Sul1, Sul2
  • VEB
  • OXA-1, GES
  • PER-1, PER-2
  • TEM
  • mecA
  • QnrA, QnrS, QnrB
  • vanA1, vanA2, vanB
  • dfrA5, dfrA1
  • FOX
  • ACC-4
  • MOX/CMY
  • LAT/CMY

References:

  1. https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/ruralurban-differences-in-antibiotic-prescribing-for-uncomplicated-urinary-tract-infection/E2927104A8CB31226B8E31339A697C7C
  2. https://www.nfid.org/antibiotic-resistance/

Let’s discuss your testing needs

Promus Diagnostics is committed to providing the highest degree of test accuracy to our patients and business clients. Whether you’re an individual looking for a test, or a Fortune 500 company searching for an end-to-end COVID testing solution, Promus is here to help.